The Anniston depot, a red brick classical revival structure, was designed by Milo R. Hanker for Southern Railway and built in 1925. The façade features a pediment over three large round-arched windows. Cream-colored stone is used for the base of the building and is also employed as trim around the windows and entryways. A marquee over the main doors protects passengers from inclement weather and is embellished with elaborate metalwork in the form of scrolls and curlicues